Ontology highlight
ABSTRACT:
SUBMITTER: Waldron TJ
PROVIDER: S-EPMC3654606 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Waldron Todd J TJ Quatromoni Jon G JG Karakasheva Tatiana A TA Singhal Sunil S Rustgi Anil K AK
Oncoimmunology 20130401 4
The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent ...[more]