Ontology highlight
ABSTRACT:
SUBMITTER: Ouyang S
PROVIDER: S-EPMC3654694 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Immunity 20120510 6
STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-mediated type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) pathway. It contains an N-terminal transmembrane region and a cytosolic C-terminal domain (CTD). Here, we describe crystal structures of STING CTD alone and complexed with c-di-GMP in a unique binding mode. The strictly conserved aa 153-173 region was shown to be cytosolic and participated in dimerizat ...[more]