Mendelian genetics of male infertility.
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ABSTRACT:
SUBMITTER: Hwang K
PROVIDER: S-EPMC3654696 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Mendelian genetics of male infertility.
Hwang Kathleen K Yatsenko Alexander N AN Jorgez Carolina J CJ Mukherjee Sarmistha S Nalam Roopa Lata RL Matzuk Martin M MM Lamb Dolores J DJ
Annals of the New York Academy of Sciences 20101201
Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive technique ...[more]
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