Ontology highlight
ABSTRACT:
SUBMITTER: Kamei M
PROVIDER: S-EPMC3654783 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kamei Michi M Nannya Yasuhito Y Torikai Hiroki H Kawase Takakazu T Taura Kenjiro K Inamoto Yoshihiro Y Takahashi Taro T Yazaki Makoto M Morishima Satoko S Tsujimura Kunio K Miyamura Koichi K Ito Tetsuya T Togari Hajime H Riddell Stanley R SR Kodera Yoshihisa Y Morishima Yasuo Y Takahashi Toshitada T Kuzushima Kiyotaka K Ogawa Seishi S Akatsuka Yoshiki Y
Blood 20080922 21
Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patients. However, the number of molecularly identified mHags is still too small to allow prospective studies ...[more]