Dataset Information

Influenza A virus induced bacterial otitis media is independent of virus tropism for ?2,6-linked sialic acid.

ABSTRACT:

Background

Otitis media (OM) affects ?80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear.

Findings

Here, we assess if the increased replication of IAV strains such as Udorn/72 in the middle ear is dependent upon the binding of the viral HA to ?2,6-linked sialic acid. Using murine and in vitro models, the present study shows that recognition of ?2,6-linked sialic acid was not required to facilitate bacterial OM.

Conclusions

Taken together, these data suggest that other features of the HA mediate bacterial OM.

SUBMITTER: Short KR

PROVIDER: S-EPMC3655017 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid.

Short Kirsty R KR Habets Marrit N MN Payne Jean J Reading Patrick C PC Diavatopoulos Dimitri A DA Wijburg Odilia L OL

Virology journal 20130423

<h4>Background</h4>Otitis media (OM) affects ≥80% of children before the age of three. OM can arise following co-infection with influenza A virus (IAV) and the bacterium Streptococcus pneumoniae. We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear.<h4>Findings</h4>Here, we assess if the increased replication of IAV strains such as ...[more]

PMID: 23617940

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