Ontology highlight
ABSTRACT:
SUBMITTER: Andersen BM
PROVIDER: S-EPMC3655124 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Andersen Brian M BM Pluhar G Elizabeth GE Seiler Charles E CE Goulart Michelle R MR SantaCruz Karen S KS Schutten Melissa M MM Meints Joyce P JP O'Sullivan M Gerard MG Bentley R Timothy RT Packer Rebecca A RA Thomovsky Stephanie A SA Chen Annie V AV Faissler Dominik D Chen Wei W Hunt Matthew A MA Olin Michael R MR Ohlfest John R JR
Cancer research 20130307 10
Malignant and atypical meningiomas are resistant to standard therapies and associated with poor prognosis. Despite progress in the treatment of other tumors with therapeutic vaccines, this approach has not been tested preclinically or clinically in these tumors. Spontaneous canine meningioma is a clinically meaningful but underutilized model for preclinical testing of novel strategies for aggressive human meningioma. We treated 11 meningioma-bearing dogs with surgery and vaccine immunotherapy co ...[more]