Ontology highlight
ABSTRACT:
SUBMITTER: Resendez E
PROVIDER: S-EPMC365541 | biostudies-literature | 1988 Oct
REPOSITORIES: biostudies-literature
Resendez E E Wooden S K SK Lee A S AS
Molecular and cellular biology 19881001 10
The gene encoding GRP78 has been shown to be constitutively expressed in many cell types and is inducible by the calcium ionophore A23187. To understand the regulation of GRP78 transcription, we analyzed the components that control its basal-level expression. By transfecting deletions into cells, we have identified a 54-nucleotide cis-acting regulatory element important for high basal-level expression and a contiguous 50-nucleotide element for both basal-level expression and A23187 induction. Us ...[more]