Discovery of common variants associated with low TSH levels and thyroid cancer risk.
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ABSTRACT:
SUBMITTER: Gudmundsson J
PROVIDER: S-EPMC3655412 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Discovery of common variants associated with low TSH levels and thyroid cancer risk.
Gudmundsson Julius J Sulem Patrick P Gudbjartsson Daniel F DF Jonasson Jon G JG Masson Gisli G He Huiling H Jonasdottir Aslaug A Sigurdsson Asgeir A Stacey Simon N SN Johannsdottir Hrefna H Helgadottir Hafdis Th HT Li Wei W Nagy Rebecca R Ringel Matthew D MD Kloos Richard T RT de Visser Marieke C H MC Plantinga Theo S TS den Heijer Martin M Aguillo Esperanza E Panadero Angeles A Prats Enrique E Garcia-Castaño Almudena A De Juan Ana A Rivera Fernando F Walters G Bragi GB Bjarnason Hjordis H Tryggvadottir Laufey L Eyjolfsson Gudmundur I GI Bjornsdottir Unnur S US Holm Hilma H Olafsson Isleifur I Kristjansson Kristleifur K Kristvinsson Hoskuldur H Magnusson Olafur T OT Thorleifsson Gudmar G Gulcher Jeffrey R JR Kong Augustine A Kiemeney Lambertus A L M LA Jonsson Thorvaldur T Hjartarson Hannes H Mayordomo Jose I JI Netea-Maier Romana T RT de la Chapelle Albert A Hrafnkelsson Jon J Thorsteinsdottir Unnur U Rafnar Thorunn T Stefansson Kari K
Nature genetics 20120122 3
To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0 ...[more]
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