Ontology highlight
ABSTRACT:
SUBMITTER: Godwin P
PROVIDER: S-EPMC3655421 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Godwin P P Baird A M AM Heavey S S Barr M P MP O'Byrne K J KJ Gately K K
Frontiers in oncology 20130516
Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug resistance proteins, reduced cellular uptake of the drug, enhanced DNA repair, intracellular drug inactivation, and evasion of apoptosis. Pre-clinical models have demonstrated that many chemotherapy drugs, such as platinum-based agents, antracyclines, and taxanes, promote the a ...[more]