Ontology highlight
ABSTRACT:
SUBMITTER: Bevington S
PROVIDER: S-EPMC3655464 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Bevington Sarah S Boyes Joan J
The EMBO journal 20130305 10
Initiation of V(D)J recombination critically relies on the formation of an accessible chromatin structure at recombination signal sequences (RSSs) but how this accessibility is generated is poorly understood. Immunoglobulin light-chain loci normally undergo recombination in pre-B cells. We show here that equipping (earlier) pro-B cells with the increased pre-B-cell levels of just one transcription factor, IRF4, triggers the entire cascade of events leading to premature light-chain recombination. ...[more]