Ontology highlight
ABSTRACT:
SUBMITTER: Zhong L
PROVIDER: S-EPMC3655627 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Zhong Li L Malani Nirav N Li Mengxin M Brady Troy T Xie Jun J Bell Peter P Li Shaoyong S Jones Haven H Wilson James M JM Flotte Terence R TR Bushman Frederic D FD Gao Guangping G
Human gene therapy 20130501 5
Recombinant adeno-associated viruses (rAAVs) have been tested in humans and other large mammals without adverse events. However, one study of mucopolysaccharidosis VII correction in mice showed repeated integration of rAAV in cells from hepatocellular carcinoma (HCC) in the Dlk1-Dio3 locus, suggesting possible insertional mutagenesis. In contrast, another study found no association of rAAV integration with HCC, raising questions about the generality of associations between liver transformation a ...[more]