Ontology highlight
ABSTRACT:
SUBMITTER: Vacchelli E
PROVIDER: S-EPMC3655739 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Vacchelli Erika E Senovilla Laura L Eggermont Alexander A Fridman Wolf Hervé WH Galon Jérôme J Zitvogel Laurence L Kroemer Guido G Galluzzi Lorenzo L
Oncoimmunology 20130301 3
It is now clear that the immune system plays a critical role not only during oncogenesis and tumor progression, but also as established neoplastic lesions respond to therapy. Selected cytotoxic chemicals can indeed elicit immunogenic cell death, a functionally peculiar type of apoptosis that stimulates tumor-specific cognate immune responses. Such immunogenic chemotherapeutics include cyclophosphamide, doxorubicin and oxaliplatin (which are approved by FDA for the treatment of various hematologi ...[more]