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A prospective study of leukocyte telomere length and risk of renal cell carcinoma.


ABSTRACT: BACKGROUND:It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively. METHODS:We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukocyte telomere length in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ORs and 95% confidence intervals (CI) were estimated using conditional logistic regression. RESULTS:Leukocyte telomere length was not significantly associated with future risk of RCC (highest quartile vs. lowest: OR, 0.8; 95% CI, 0.5-1.5; Ptrend = 0.6). Analyses stratified by sex, age, and time from blood collection to RCC diagnosis were similarly null. CONCLUSIONS:The results of this study, to our knowledge the first prospective investigation of its kind, do not support an association between prediagnostic leukocyte telomere length and risk of RCC. IMPACT:In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of RCC.

SUBMITTER: Hofmann JN 

PROVIDER: S-EPMC3655903 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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A prospective study of leukocyte telomere length and risk of renal cell carcinoma.

Hofmann Jonathan N JN   Lan Qing Q   Cawthon Richard R   Hosgood H Dean HD   Shuch Brian B   Moore Lee E LE   Rothman Nathaniel N   Chow Wong-Ho WH   Purdue Mark P MP  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20130319 5


<h4>Background</h4>It has been hypothesized that genomic instability related to telomere dysfunction may contribute to carcinogenesis. There is some evidence from case-control studies suggesting that short leukocyte telomere length may be associated with an increased risk of renal cell carcinoma (RCC); however, this association has not been investigated prospectively.<h4>Methods</h4>We conducted a nested case-control study (209 cases, 410 controls) of RCC risk in relation to prediagnostic leukoc  ...[more]

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