Ontology highlight
ABSTRACT:
SUBMITTER: Jiao S
PROVIDER: S-EPMC3655968 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Jiao Shihui S Chu Qin Q Wang Yachun Y Xie Zhenquan Z Hou Shiyu S Liu Airong A Wu Hongjun H Liu Lin L Geng Fanjun F Wang Congyong C Qin Chunhua C Tan Rui R Huang Xixia X Tan Shixin S Wu Meng M Xu Xianzhou X Liu Xuan X Yu Ying Y Zhang Yuan Y
PloS one 20130516 5
Arachnomelia syndrome (AS), mainly found in Brown Swiss and Simmental cattle, is a congenital lethal genetic malformation of the skeletal system. In this study, a network-based disease gene prioritization approach was implemented to rank genes in the previously reported ∼7 Mb region on chromosome 23 associated with AS in Simmental cattle. The top 6 ranked candidate genes were sequenced in four German Simmental bulls, one known AS-carrier ROMEL and a pooled sample of three known non-carriers (BOS ...[more]