Ontology highlight
ABSTRACT:
SUBMITTER: Meng W
PROVIDER: S-EPMC3655971 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Meng Wei W McElroy Joseph P JP Volinia Stefano S Palatini Jeff J Warner Sarah S Ayers Leona W LW Palanichamy Kamalakannan K Chakravarti Arnab A Lautenschlaeger Tim T
PloS one 20130516 5
MicroRNAs regulate several aspects of tumorigenesis and cancer progression. Most cancer tissues are archived formalin-fixed and paraffin-embedded (FFPE). While microRNAs are a more stable form of RNA thought to withstand FFPE-processing and degradation there is only limited evidence for the latter assumption. We examined whether microRNA profiling can be successfully conducted on FFPE cancer tissues using SOLiD ligation based sequencing. Tissue storage times (2-9 years) appeared to not affect th ...[more]