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Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.

ABSTRACT: Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its distribution is derived from a uniform, and it is easy to estimate from experimental data. We show how it can be cast into a test for recent selective sweeps using microsatellite markers and present an application to an experimental data set from Plasmodium falciparum.

SUBMITTER: Li H 

PROVIDER: S-EPMC3656098 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.

Li Haipeng H   Wiehe Thomas T  

PLoS computational biology 20130516 5

Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its distribution is derived from a uniform, and it is easy to estimate from experimental data. We show how it can be cast into a test for recent selective sweeps using microsatellite markers and present an application to an experimental data set fro  ...[more]