Differential activation of diverse glutathione transferases of Clonorchis sinensis in response to the host bile and oxidative stressors.

ABSTRACT:

Background

Clonorchis sinensis causes chronic cumulative infections in the human hepatobiliary tract and is intimately associated with cholangiocarcinoma. Approximately 35 million people are infected and 600 million people are at risk of infections worldwide. C. sinensis excretory-secretory products (ESP) constitute the first-line effector system affecting the host-parasite interrelationship by interacting with bile fluids and ductal epithelium. However, the secretory behavior of C. sinensis in an environment close to natural host conditions is unclear. C. sinensis differs from Fasciola hepatica in migration to, and maturation in, the hepatic bile duct, implying that protein profile of the ESP of these two trematodes might be different from each other.

Methodology/principal find

SUBMITTER: Bae YA 

PROVIDER: S-EPMC3656158 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature