Ontology highlight
ABSTRACT:
SUBMITTER: Cestari I
PROVIDER: S-EPMC3656282 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20130402 20
Trypanosoma brucei sp. causes human African trypanosomiasis (HAT; African sleeping sickness). The parasites initially proliferate in the hemolymphatic system and then invade the central nervous system, which is lethal if not treated. New drugs are needed for HAT because the approved drugs are few, toxic, and difficult to administer, and drug resistance is spreading. We showed by RNAi knockdown that T. brucei isoleucyl-tRNA synthetase is essential for the parasites in vitro and in vivo in a mouse ...[more]