Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC3657305 | biostudies-literature | 2013 Mar-Apr
REPOSITORIES: biostudies-literature
Liu Minmin M Doublié Sylvie S Wallace Susan S SS
Mutation research 20121226
DNA glycosylases are the enzymes that initiate the Base Excision Repair (BER) process that protects all organisms from the mutagenic and/or cytotoxic effects of DNA base lesions. Endonuclease VIII like proteins (Neil1, Neil2 and Neil3) are found in vertebrate genomes and are homologous to the well-characterized bacterial DNA glycosylases, Formamidopyrimidine DNA glycosylase (Fpg) and Endonuclease VIII (Nei). Since the initial discovery of the Neil proteins, much progress has been made on charact ...[more]