Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.
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ABSTRACT:
SUBMITTER: Grimm D
PROVIDER: S-EPMC365757 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Publications
Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.
Grimm Dorothee D Tilly Kit K Byram Rebecca R Stewart Philip E PE Krum Jonathan G JG Bueschel Dawn M DM Schwan Tom G TG Policastro Paul F PF Elias Abdallah F AF Rosa Patricia A PA
Proceedings of the National Academy of Sciences of the United States of America 20040217 9
Environmentally responsive synthesis of surface proteins represents a hallmark of the infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and analyzed a B. burgdorferi mutant lacking outer-surface protein C (OspC), an abundant Osp that spirochetes normally synthesize in the tick vector during the blood meal and down-regulate after transmission to the mammal. We demonstrate that B. burgdorferi strictly requires OspC to infect mice but not to localize or migrate appro ...[more]
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