Cooperative melting in caged dimers with only two DNA duplexes.
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ABSTRACT:
SUBMITTER: Eryazici I
PROVIDER: S-EPMC3657612 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Cooperative melting in caged dimers with only two DNA duplexes.
Eryazici Ibrahim I Prytkova Tatiana R TR Schatz George C GC Nguyen SonBinh T ST
Journal of the American Chemical Society 20101112 48
Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model. ...[more]
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