Dataset Information

Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA.

ABSTRACT:

Objectives

Determine whether body mass index (BMI) and physical activity (PA) above, at or below MET minute per week (MMW) levels recommended in the 2008 Physical Activity Guidelines interact or have additive effects on interleukin (IL)-6, C reactive protein (CRP), fibrinogen, interleukin6 (IL-6) soluble receptor (IL-6sr), soluble E-selectin and soluble intracellular adhesion molecule (sICAM)-1.

Design

Archived cohort data (n=1254, age 54.5±11.7 year, BMI 29.8±6.6 kg/m(2)) from the National Survey of Midlife Development in the USA (MIDUS) Biomarkers Study were analysed for concentrations of inflammatory markers using general linear models. MMW was defined as no regular exercise, <500 MMW, 500-1000 MMW, >1000 MMW and BMI was defined as <25, 25-29.9, ?30 kg/m(2). Analyses were adjusted for age, sex, smoking and relevant medication use.

Setting

Respondents reported to three centres to complete questionnaires and provide blood samples.

Participants

Participants were men and women currently enroled in the MIDUS Biomarker Project (n=1254, 93% non-Hispanic white, average age 54.5 years).

Primary outcome measures

Concentration of serum IL-6, CRP, fibrinogen, IL-6sr, sE-selectin and sICAM.

Results

Significant interactions were found between BMI and MMW for CRP and sICAM-1 (p<0.05). CRP in overweight individuals was similar to that in obese individuals when no PA was reported, but it was similar to normal weight when any level of regular PA was reported. sICAM-1 was differentially lower in obese individuals who reported >1000 MMW compared to obese individuals reporting less exercise.

Conclusions

The association of exercise with CRP and sICAM-1 differed by BMI, suggesting that regular exercise may buffer weight-associated elevations in CRP in overweight individuals while higher levels of exercise may be necessary to reduce sICAM-1 or CRP in obese individuals.

SUBMITTER: Strohacker K

PROVIDER: S-EPMC3657650 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA.

Strohacker Kelley K Wing Rena R RR McCaffery Jeanne M JM

BMJ open 20130528 5

<h4>Objectives</h4>Determine whether body mass index (BMI) and physical activity (PA) above, at or below MET minute per week (MMW) levels recommended in the 2008 Physical Activity Guidelines interact or have additive effects on interleukin (IL)-6, C reactive protein (CRP), fibrinogen, interleukin6 (IL-6) soluble receptor (IL-6sr), soluble E-selectin and soluble intracellular adhesion molecule (sICAM)-1.<h4>Design</h4>Archived cohort data (n=1254, age 54.5±11.7 year, BMI 29.8±6.6 kg/m(2)) from th ...[more]

PMID: 23793684

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Project description:There is evidence that insufficient sleep and more stressors are individually associated with poor metabolic health outcomes. Examining sleep and stressors jointly may account for greater variability in health outcomes; however, we know little about the combined effect of both insufficient sleep and more stressors on metabolic health. This study examined whether experiencing more stressors in response to insufficient sleep ("stressor reactivity to insufficient sleep") was associated with body mass index in middle-aged workers. One-hundred and twenty-seven participants (Mage = 45.24 ± 6.22 years) reported nightly sleep characteristics and daily stressors on 8 consecutive days. We collected height and weight measurements to calculate body mass index (kg m-2 ). On average, workers reported more stressors following nights with shorter-than-usual sleep duration or poorer-than-usual sleep quality (negative slope means higher stressor reactivity to insufficient sleep). When examining stressor reactivity to insufficient sleep with insufficient sleep represented by shorter-than-usual sleep duration, compared with those with average stressor reactivity to insufficient sleep (within ±½ SD; reference), workers with high stressor reactivity to insufficient sleep (≤-½ SD) had higher body mass index (B = 3.24, p < .05). The body mass index of these workers fell in the obese range. There was no difference in body mass index between workers with low stressor reactivity to insufficient sleep (≥+½ SD) and the reference group. When examining stressor reactivity to insufficient sleep with insufficient sleep represented by poorer-than-usual sleep quality, stressor reactivity to insufficient sleep was not significantly associated with body mass index. Results suggest that middle-aged workers with higher stressor reactivity to insufficient sleep duration may be at greater risk for obesity. Results may inform future studies on interventions for improving sleep and reducing stress in middle-aged workers.

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Dataset Information

Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA.

Objectives

Design

Setting

Participants

Primary outcome measures

Results

Conclusions

Publications

Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA.

Similar Datasets

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