Ontology highlight
ABSTRACT:
SUBMITTER: Mehta D
PROVIDER: S-EPMC3657772 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Mehta Divya D Mehta Divya D Klengel Torsten T Conneely Karen N KN Smith Alicia K AK Altmann André A Pace Thaddeus W TW Rex-Haffner Monika M Loeschner Anne A Gonik Mariya M Mercer Kristina B KB Bradley Bekh B Müller-Myhsok Bertram B Ressler Kerry J KJ Binder Elisabeth B EB
Proceedings of the National Academy of Sciences of the United States of America 20130429 20
Childhood maltreatment is likely to influence fundamental biological processes and engrave long-lasting epigenetic marks, leading to adverse health outcomes in adulthood. We aimed to elucidate the impact of different early environment on disease-related genome-wide gene expression and DNA methylation in peripheral blood cells in patients with posttraumatic stress disorder (PTSD). Compared with the same trauma-exposed controls (n = 108), gene-expression profiles of PTSD patients with similar clin ...[more]