Ontology highlight
ABSTRACT:
SUBMITTER: Arambula D
PROVIDER: S-EPMC3657778 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Arambula Diego D Wong Wenge W Medhekar Bob A BA Guo Huatao H Gingery Mari M Czornyj Elizabeth E Liu Minghsun M Dey Sanghamitra S Ghosh Partho P Miller Jeff F JF
Proceedings of the National Academy of Sciences of the United States of America 20130430 20
Diversity-generating retroelements (DGRs) are a unique family of retroelements that confer selective advantages to their hosts by facilitating localized DNA sequence evolution through a specialized error-prone reverse transcription process. We characterized a DGR in Legionella pneumophila, an opportunistic human pathogen that causes Legionnaires disease. The L. pneumophila DGR is found within a horizontally acquired genomic island, and it can theoretically generate 10(26) unique nucleotide seque ...[more]