Ontology highlight
ABSTRACT:
SUBMITTER: Kurashima Y
PROVIDER: S-EPMC3658010 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nature communications 20120101
Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 purinoceptors. We find an increase in the numbers of mast cells expressing P2X7 purinoceptors in the colons of mice with colitis and of patients with Crohn's disease. Treatment of mice with a P2X7 purinoceptor-specific antibody inhibits mast cell activati ...[more]