Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC3658166 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Chen Zhao Z Tang Hua H Qayyum Rehan R Schick Ursula M UM Nalls Michael A MA Handsaker Robert R Li Jin J Lu Yingchang Y Yanek Lisa R LR Keating Brendan B Meng Yan Y van Rooij Frank J A FJ Okada Yukinori Y Kubo Michiaki M Rasmussen-Torvik Laura L Keller Margaux F MF Lange Leslie L Evans Michele M Bottinger Erwin P EP Linderman Michael D MD Ruderfer Douglas M DM Hakonarson Hakon H Papanicolaou George G Zonderman Alan B AB Gottesman Omri O Thomson Cynthia C Ziv Elad E Singleton Andrew B AB Loos Ruth J F RJ Sleiman Patrick M A PM Ganesh Santhi S McCarroll Steven S Becker Diane M DM Wilson James G JG Lettre Guillaume G Reiner Alexander P AP
Human molecular genetics 20130226 12
Laboratory red blood cell (RBC) measurements are clinically important, heritable and differ among ethnic groups. To identify genetic variants that contribute to RBC phenotypes in African Americans (AAs), we conducted a genome-wide association study in up to ~16 500 AAs. The alpha-globin locus on chromosome 16pter [lead SNP rs13335629 in ITFG3 gene; P < 1E-13 for hemoglobin (Hgb), RBC count, mean corpuscular volume (MCV), MCH and MCHC] and the G6PD locus on Xq28 [lead SNP rs1050828; P < 1E - 13 f ...[more]