Ontology highlight
ABSTRACT:
SUBMITTER: Iskar M
PROVIDER: S-EPMC3658274 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Iskar Murat M Iskar Murat M Zeller Georg G Blattmann Peter P Campillos Monica M Kuhn Michael M Kaminska Katarzyna H KH Runz Heiko H Gavin Anne-Claude AC Pepperkok Rainer R van Noort Vera V Bork Peer P
Molecular systems biology 20130101
In pharmacology, it is crucial to understand the complex biological responses that drugs elicit in the human organism and how well they can be inferred from model organisms. We therefore identified a large set of drug-induced transcriptional modules from genome-wide microarray data of drug-treated human cell lines and rat liver, and first characterized their conservation. Over 70% of these modules were common for multiple cell lines and 15% were conserved between the human in vitro and the rat i ...[more]