Ontology highlight
ABSTRACT:
SUBMITTER: Meng Z
PROVIDER: S-EPMC3659100 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Meng Zhongji Z Zhang Xiaoyong X Wu Jun J Pei Rongjuan R Xu Yang Y Yang Dongliang D Roggendorf Michael M Lu Mengji M
PloS one 20130520 5
<h4>Background aims</h4>Our previous results showed that the knockdown of woodchuck hepatitis virus (WHV) by RNA interference (RNAi) led to upregulation of interferon stimulated genes (ISGs) in primary hepatocytes. In the present study, we tested the hypothesis that the cellular signaling pathways recognizing RNA molecules may be involved the ISG stimulation by RNAi.<h4>Methods</h4>Primary murine hepatocytes (PMHs) from wild type mice and WHV transgenic (Tg) mice were prepared and treated with d ...[more]