Ontology highlight
ABSTRACT:
SUBMITTER: Kurihara T
PROVIDER: S-EPMC3659356 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Kurihara Tomohiro T Jones Caroline N CN Yu Yong-Ming YM Fischman Alan J AJ Watada Susumu S Tompkins Ronald G RG Fagan Shawn P SP Irimia Daniel D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130221 6
Following severe burns and trauma injuries, the changes of neutrophil migratory phenotype are a double-edged sword. Activated neutrophils migrate into injured tissues and help contain microbial infections, but they can also enter normal tissues and damage vital organs. Depleting the neutrophils from circulation protects vital organs against neutrophil-induced damage but leaves the body exposed to infectious complications. Here we show that restoring normal neutrophil migratory phenotype in rats ...[more]