Ontology highlight
ABSTRACT:
SUBMITTER: Kim JD
PROVIDER: S-EPMC3659797 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20120801 2
Bone morphogenetic proteins (BMPs) have diverse functions during development in vertebrates. We have recently shown that BMP2 signaling promotes venous-specific angiogenesis in zebrafish embryos. However, factors that confer a context-dependent proangiogenic function of BMP2 signaling within endothelial cells need to be identified. Here, we report that Disabled homolog 2 (Dab2), a cargo-specific adaptor protein for Clathrin, is essential to mediate the proangiogenic function of BMP2 signaling. W ...[more]