Ontology highlight
ABSTRACT:
SUBMITTER: Rhinn H
PROVIDER: S-EPMC3660047 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rhinn Herve H Qiang Liang L Yamashita Toru T Rhee David D Zolin Ari A Vanti William W Abeliovich Asa A
Nature communications 20120101
α-Synuclein is implicated both in physiological functions at neuronal synaptic terminals as well as in pathological processes in the context of Parkinson's disease. However, the molecular mechanisms for these apparently diverse roles are unclear. Here we show that specific RNA transcript isoforms of α-synuclein with an extended 3' untranslated region, termed aSynL, appear selectively linked to pathological processes, relative to shorter α-synuclein transcripts. Common variants in the aSynL 3' un ...[more]