MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3660136 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.
Zhang Lu L Sun Zhi-Jun ZJ Bian Yansong Y Kulkarni Ashok B AB
Cancer letters 20130120 2
Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis revealed that miR-135b affects a regulator that inhibits hypoxia-inducible factor (HIF). Increased miR-135b expression was positively correlated with HIF-1α expression and microvessel ...[more]
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