Ontology highlight
ABSTRACT:
SUBMITTER: Han SW
PROVIDER: S-EPMC3660257 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Han Sae-Won SW Kim Hwang-Phill HP Shin Jong-Yeon JY Jeong Eun-Goo EG Lee Won-Chul WC Lee Kyung-Hun KH Won Jae-Kyung JK Kim Tae-Yong TY Oh Do-Youn DY Im Seock-Ah SA Bang Yung-Jue YJ Jeong Seung-Yong SY Park Kyu Joo KJ Park Jae-Gahb JG Kang Gyeong Hoon GH Seo Jeong-Sun JS Kim Jong-Il JI Kim Tae-You TY
PloS one 20130521 5
Recent advance in sequencing technology has enabled comprehensive profiling of genetic alterations in cancer. We have established a targeted sequencing platform using next-generation sequencing (NGS) technology for clinical use, which can provide mutation and copy number variation data. NGS was performed with paired-end library enriched with exons of 183 cancer-related genes. Normal and tumor tissue pairs of 60 colorectal adenocarcinomas were used to test feasibility. Somatic mutation and copy n ...[more]