Dataset Information

MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients.

ABSTRACT:

Background

In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways.

Design and methods

We analyzed eight miR-SNPs by allelic discrimination in 141 patients with Hodgkin lymphoma and correlated the results with treatment-related toxicity, response, disease-free survival (DFS) and overall survival (OS).

Results

The KRT81 (rs3660) GG genotype was associated with an increased risk of neurological toxicity (P?=?0.016), while patients with XPO5 (rs11077) AA or CC genotypes had a higher rate of bleomycin-associated pulmonary toxicity (P?=?0.048). Both miR-SNPs emerged as independent factors in the multivariate analysis. The XPO5 AA and CC genotypes were also associated with a lower response rate (P?=?0.036). XPO5 (P?=?0.039) and TRBP (rs784567) (P?=?0.022) genotypes emerged as prognostic markers for DFS, and XPO5 was also associated with OS (P?=?0.033). In the multivariate analysis, only XPO5 emerged as an independent prognostic factor for DFS (HR: 2.622; 95%CI 1.039-6.620; P?=?0.041). Given the influence of XPO5 and TRBP as individual markers, we then investigated the combined effect of these miR-SNPs. Patients with both the XPO5 AA/CC and TRBP TT/TC genotypes had the shortest DFS (P?=?0.008) and OS (P?=?0.008).

Conclusion

miR-SNPs can add useful prognostic information on treatment-related toxicity and clinical outcome in Hodgkin lymphoma and can be used to identify patients likely to be chemoresistant or to relapse.

SUBMITTER: Navarro A

PROVIDER: S-EPMC3660374 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients.

Navarro Alfons A Muñoz Carmen C Gaya Anna A Díaz-Beyá Marina M Gel Bernat B Tejero Rut R Díaz Tania T Martinez Antonio A Monzó Mariano M

PloS one 20130521 5

<h4>Background</h4>In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways.<h4>Design and methods</h4>We analyzed eight miR-SNPs by allelic discrimination in 141 patients with Hodgkin lymphoma and correlated the results with treatment-related toxicity, response, disease-free survival (DFS) and overall survival (OS).<h4>Results</h4>The KRT81 (rs3660 ...[more]

PMID: 23705004

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Project description:PurposeRadiation therapy (RT) improves control of Hodgkin lymphoma (HL), but patients who undergo RT are at risk for late effects, including cardiovascular disease and second cancers, because of radiation doses to organs at risk (OARs). Proton therapy (PT) can reduce OAR doses compared with conventional photon RT. However, access to PT is currently limited, so referrals must be appropriately selective. We aimed to identify subgroups of patients with HL who could benefit the most dosimetrically from RT with PT based on the prechemotherapy disease characteristics.Methods and materialsNormal tissue radiation doses were calculated for 21 patients with HL who were treated with deep-inspiration breath-hold pencil-beam scanning (PBS) PT and compared with doses from 3-dimensional conformal (3D-CRT) and partial arc volumetric modulated (PartArc) photon RT. Prechemotherapy disease characteristics associated with significant dosimetric benefits from PBS compared with photon RT were identified.ResultsTreatment with PBS was well tolerated and provided with good local control. PBS provided dosimetric advantages for patients whose clinical treatment volume extended below the seventh thoracic level and for female patients with axillary disease. In addition, an increasing dosimetric benefit for some OARs was observed for increasing target volume. PBS significantly reduced the mean dose to the heart, breast, lungs, spinal cord, and esophagus. Dose homogeneity and conformity within the target volume were also superior with PBS, but some high-dose measures and hot spots were increased with PBS compared with partial arc volumetric modulated photon RT.ConclusionsPBS gives good target coverage and local control while providing reductions in radiation dose to OARs for individuals who receive RT for HL compared with advanced photon RT. Our findings highlight groups of patients who would be expected to gain more dosimetric benefit from PBS. These findings facilitate the selection of patients who should be considered a priority for PT.

Dataset Information

MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients.

Background

Design and methods

Results

Conclusion

Publications

MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients.

Similar Datasets

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