The influenza virus protein PB1-F2 interacts with IKK? and modulates NF-?B signalling.
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ABSTRACT:
SUBMITTER: Reis AL
PROVIDER: S-EPMC3660569 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
The influenza virus protein PB1-F2 interacts with IKKβ and modulates NF-κB signalling.
Reis Ana Luísa AL McCauley John W JW
PloS one 20130521 5
PB1-F2, a protein encoded by a second open reading frame of the influenza virus RNA segment 2, has emerged as a modulator of lung inflammatory responses but the molecular mechanisms underlying this are only poorly understood. Here we show that PB1-F2 inhibits the activation of NF-κB dependent signalling pathways in luciferase reporter assays. PB1-F2 proteins from four different viruses interact with IKKβ in yeast two-hybrid assays and by co-immunoprecipitation. PB1-F2 expression did not inhibit ...[more]
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