XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis.

ABSTRACT:

Background

A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive. We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population.

Methodology/principal findings

The association strength was measured with odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of 9 eligible studies, conducted in China, India and Japan, were identified. We observed a significant increased risk of bladder cancer in dominant model (OR?=?1.199, 95% CI: 1.021,1.408, Pheterogeneity?=?0.372), allele comparison (OR?=?1.200, 95% CI: 1.057,1.362, Pheterogeneity?=?0.107) of Arg194Trp, heterozygote comparison (OR?=?1.869, 95% CI: 1.205,2.898, Pheterogeneity?=?0.011) and dominant model (OR?=?1.748, 95% CI: 1.054,2.900, Pheterogeneity?=?0.01) of Arg280His. Pooled results estimated from adjusted ORs further validated these findings. No publication bias was detected. Subgroup analyses found that significant increased risk was only found among community-based studies not hospital-based studies. There was no evidence of publication bias.

Conclusion

This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer. Our meta-analysis shows that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with a significantly increased risk of bladder cancer in Asian population.

SUBMITTER: Fang Z 

PROVIDER: S-EPMC3660573 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature