Ontology highlight
ABSTRACT:
SUBMITTER: Mariappa D
PROVIDER: S-EPMC3660836 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Science signaling 20111220 204
Glycosylation is essential for growth factor signaling through N-glycosylation of ligands and receptors and the biosynthesis of proteoglycans as co-receptors. Here, we show that protein O-GlcNAcylation is crucial for fibroblast growth factor (FGF) signaling in Drosophila. We found that nesthocker (nst) encodes a phosphoacetylglucosamine mutase and that nst mutant embryos exhibited low amounts of intracellular uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc), which disrupted protein O-GlcN ...[more]