MiR-506 regulates epithelial mesenchymal transition in breast cancer cell lines.

ABSTRACT: Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF-?B bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGF?-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes.

SUBMITTER: Arora H 

PROVIDER: S-EPMC3661463 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature