Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC3662010 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Yun Y Dodd Stephen J SJ Tangrea Michael A MA Emmert-Buck Michael R MR Koretsky Alan P AP
Scientific reports 20130101
Collective cell behaviors in migration and force generation were studied at the mesoscopic-level using cells grown in a 3D extracellular matrix (ECM) simulating tissues. Magnetic resonance imaging (MRI) was applied to investigate dynamic cell mechanics at this level. MDCK, NBT2, and MEF cells were embedded in 3D ECM, forming clusters that then migrated and generated forces affecting the ECM. The cells demonstrated MRI contrast due to iron accumulation in the clusters. Timelapse-MRI enabled the m ...[more]