Ontology highlight
ABSTRACT:
SUBMITTER: Kamenetsky M
PROVIDER: S-EPMC3662476 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Kamenetsky Margarita M Middelhaufe Sabine S Bank Erin M EM Levin Lonny R LR Buck Jochen J Steegborn Clemens C
Journal of molecular biology 20060728 4
The second messenger cAMP has been extensively studied for half a century, but the plethora of regulatory mechanisms controlling cAMP synthesis in mammalian cells is just beginning to be revealed. In mammalian cells, cAMP is produced by two evolutionary related families of adenylyl cyclases, soluble adenylyl cyclases (sAC) and transmembrane adenylyl cyclases (tmAC). These two enzyme families serve distinct physiological functions. They share a conserved overall architecture in their catalytic do ...[more]