Information-optimal transcriptional response to oscillatory driving.
Ontology highlight
ABSTRACT:
SUBMITTER: Mugler A
PROVIDER: S-EPMC3662809 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Information-optimal transcriptional response to oscillatory driving.
Mugler Andrew A Walczak Aleksandra M AM Wiggins Chris H CH
Physical review letters 20100729 5
Intracellular transmission of information via chemical and transcriptional networks is thwarted by a physical limitation: The finite copy number of the constituent chemical species introduces unavoidable intrinsic noise. Here we solve for the complete probabilistic description of the intrinsically noisy response to an oscillatory driving signal. We derive and numerically verify a number of simple scaling laws. Unlike in the case of measuring a static quantity, response to an oscillatory signal c ...[more]
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