Janus kinase 2 polymorphisms are associated with risk in patients with gastric cancer in a Chinese population.

ABSTRACT:

Aim

To evaluate the impact of the Janus kinase 2 single nucleotide polymorphisms (SNPs) on gastric cancer risk.

Methods

In this hospital-based, case-control study, the genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism protocols in 661 individuals (359 gastric cancer patients and 302 age and sex matched cancer-free controls).

Results

Both the frequency of A allele in rs2230724 and G allele in rs1887427 were more frequent in patients with gastric cancer (P?=?0.013 and 0.001, respectively). Compared with the common genotype, subjects with the (AG+AA) genotypes of rs2230724 and the (AG+GG) genotypes of rs1887427 had a 59% and 98% increased risk of developing gastric cancer, respectively (P?=?0.010, adjusted OR?=?1.59, 95% CI?=?1.12-2.27; P<0.001, adjusted OR?=?1.98, 95% CI?=?1.39-2.81, respectively). Further stratified analysis showed that the association between the risk of gastric cancer and the rare genotypes of rs2230724 were more profound in the subgroups of elder individuals (>56 years), males, nonsmokers and urban subjects, while the association between the risk and the rare genotypes of rs1887427 persisted in subgroups of younger individuals (?56 years), males, nonsmokers and both of rural and urban subjects.

Conclusion

The JAK2 gene rs2230724 and rs1887427 polymorphisms are associated with an increased risk of gastric cancer in a Chinese Han population.

SUBMITTER: Yang L 

PROVIDER: S-EPMC3663844 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature