Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity.
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ABSTRACT:
SUBMITTER: Almabruk KH
PROVIDER: S-EPMC3663920 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity.
Almabruk Khaled H KH Lu Wanli W Li Yuexin Y Abugreen Mostafa M Kelly Jane X JX Mahmud Taifo T
Organic letters 20130322 7
A mutasynthetic strategy has been used to generate fluorinated TM-025 and TM-026, two biosynthetically engineered pactamycin analogues produced by Streptomyces pactum ATCC 27456. The fluorinated compounds maintain excellent activity and selectivity toward chloroquine-sensitive and multidrug-resistant strains of malarial parasites as the parent compounds. The results also provide insights into the biosynthesis of 3-aminobenzoic acid in S. pactum. ...[more]
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