Ontology highlight
ABSTRACT:
SUBMITTER: Kolev NG
PROVIDER: S-EPMC3664091 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kolev Nikolay G NG Ramey-Butler Kiantra K Cross George A M GA Ullu Elisabetta E Tschudi Christian C
Science (New York, N.Y.) 20121201 6112
Unraveling the intricate interactions between Trypanosoma brucei, the protozoan parasite causing African trypanosomiasis, and the tsetse (Glossina) vector remains a challenge. Metacyclic trypanosomes, which inhabit the tsetse salivary glands, transmit the disease and are produced through a complex differentiation and unknown program. By overexpressing a single RNA-binding protein, TbRBP6, in cultured noninfectious trypanosomes, we recapitulated the developmental stages that have been observed in ...[more]