Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Busnadiego R
PROVIDER: S-EPMC3664715 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20130501 5
Synaptic vesicles are embedded in a complex filamentous network at the presynaptic terminal. Before fusion, vesicles are linked to the active zone (AZ) by short filaments (tethers). The identity of the molecules that form and regulate tethers remains unknown, but Rab3-interacting molecule (RIM) is a prominent candidate, given its central role in AZ organization. In this paper, we analyzed presynaptic architecture of RIM1α knockout (KO) mice by cryo-electron tomography. In stark contrast to previ ...[more]