Ontology highlight
ABSTRACT:
SUBMITTER: Zhao ZZ
PROVIDER: S-EPMC3665505 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Zhao Zhen Zhen ZZ Duffy David L DL Thomas Shane A SA Martin Nicholas G NG Hayward Nicholas K NK Montgomery Grant W GW
Melanoma research 20090401 2
The prevalence of cutaneous malignant melanoma (CMM) has increased significantly in most Caucasian populations in recent decades. Both genetic and environmental risk factors are involved in the development of CMM. A germline mutation in the syntaxin 17 (STX17) gene of horses was recently identified, which causes premature hair graying and is associated with susceptibility to melanoma. We hypothesized that common germline variants in the STX17 gene might be associated with a predisposition to hum ...[more]