Ontology highlight
ABSTRACT:
SUBMITTER: Korecka JA
PROVIDER: S-EPMC3665836 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Korecka Joanna A JA van Kesteren Ronald E RE Blaas Eva E Spitzer Sonia O SO Kamstra Jorke H JH Smit August B AB Swaab Dick F DF Verhaagen Joost J Bossers Koen K
PloS one 20130528 5
Multiple genetic and environmental factors play a role in the development and progression of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta. To study genetic and molecular contributors to the disease process, there is a great need for readily accessible cells with prominent DAergic features that can be used for reproducible in vitro cellular screening. Here, we investigated the molecu ...[more]