Ontology highlight
ABSTRACT:
SUBMITTER: Demogines A
PROVIDER: S-EPMC3665890 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Demogines Ann A Abraham Jonathan J Choe Hyeryun H Farzan Michael M Sawyer Sara L SL
PLoS biology 20130528 5
Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of multiple mammalian viruses. We use evolutionary and functional analyses of TfR1 in the rodent clade, where two families of viruses bind this receptor, to mechanistically dissect how essential housekeeping genes like TFR1 successfully balance the opposing selective pressures exerted by host and virus. We find th ...[more]