Ontology highlight
ABSTRACT:
SUBMITTER: Van den Veyver IB
PROVIDER: S-EPMC3665952 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Van den Veyver Ignatia B IB Patel Ankita A Shaw Chad A CA Pursley Amber N AN Kang Sung-Hae L SH Simovich Marcia J MJ Ward Patricia A PA Darilek Sandra S Johnson Anthony A Neill Sarah E SE Bi Weimin W White Lisa D LD Eng Christine M CM Lupski James R JR Cheung Sau Wai SW Beaudet Arthur L AL
Prenatal diagnosis 20090101 1
<h4>Objective</h4>To evaluate the use of array comparative genomic hybridization (aCGH) for prenatal diagnosis, including assessment of variants of uncertain significance, and the ability to detect abnormalities not detected by karyotype, and vice versa.<h4>Methods</h4>Women undergoing amniocentesis or chorionic villus sampling (CVS) for karyotype were offered aCGH analysis using a targeted microarray. Parental samples were obtained concurrently to exclude maternal cell contamination and determi ...[more]