Ontology highlight
ABSTRACT:
SUBMITTER: Barnhart KF
PROVIDER: S-EPMC3666164 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Barnhart Kirstin F KF Christianson Dawn R DR Hanley Patrick W PW Driessen Wouter H P WH Bernacky Bruce J BJ Baze Wallace B WB Wen Sijin S Tian Mei M Ma Jingfei J Kolonin Mikhail G MG Saha Pradip K PK Do Kim-Anh KA Hulvat James F JF Gelovani Juri G JG Chan Lawrence L Arap Wadih W Pasqualini Renata R
Science translational medicine 20111101 108
Obesity, defined as body mass index greater than 30, is a leading cause of morbidity and mortality and a financial burden worldwide. Despite significant efforts in the past decade, very few drugs have been successfully developed for the treatment of obese patients. Biological differences between rodents and primates are a major hurdle for translation of anti-obesity strategies either discovered or developed in rodents into effective human therapeutics. Here, we evaluate the ligand-directed pepti ...[more]